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The 4th Generation 785nm Handheld Raman Analyzer (450g)
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Product Code: ATR6500


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ATR6500 is designed ultra-thin, lightweight, smart handheld Raman system. 

The total weight is less than 0.6kg, compact size suit to be operated by a single hand and easy-to-take. It can fast detect pharmaceutical drugs, precursor chemicals, explosives, gemstones, raw materials whether in industries of customs, public safety, lab, factory plant, warehouse, deck. Users can also make fast detect additives, pesticide residues, veterinary drugs residues, etc.

ATR6500 built-in advanced algorithm can easy to detect any substance, users can also add a spectral library by their own. 

It employs Android system, simple interface, 5.5-inch high-resolution screen, a high-definition double camera of 13-mega and 8-mega, available in keeping a record of field site at any time, built-in WIFI, blue-tooth, GPS, and users can experience intelligent operation.

Technical parameters:
Technique:  Raman Spectra Analysis Technique
Wavelength:   785nm
Spectral range:  200-4000cm-1
Resolution:  10cm-1
Dimension:   176x80x30mm
Pharmaceutical drugs:Heroin, Cocaine, Metamfetamine, Ketamin etc.
Precursor:(-)-ephedrine, Chloroform,Diethyl ether etc.
Explosives:TNT,RDX,TATP, Ammonium nitrate etc.
Hazardous chemicals:Sulfate, Gasoline, Nitric acid, Toluene, etc.
Gemstones:Diamond, Agate, Emerald, etc.
Food Safety:Illegal food additives, pesticide residues, veterinary drugs residues etc.
Self-built library:Users can add a spectral library by their own
Detect Result:  Export informational detect report(detect result, spectra info, picture evident)
Interface:  4G, WiFi, Bluetooth, Micro USB
Power: Chargeable Li-battery, life span:4-6hrs
Operating Temp:   -20-50℃
Pixels dimension 2048 pixels
Detector model S11639
Raman Instrument
Operating system Android
Excitation Wavelength 785 ± 0.5nm
Wavenumber Range 200-4000 cm-1
Resolution 11 cm-1
Touch Screen 5.5" touch screen, 1920×1080, c
Weight 450g
Size 6.7"×3.1"×1.2"
Dynamic Range 5000:1
Interface WIFI, USB Type-C, Bluetooth, GSM
Library 1.Scientific Research Self-built Spectral Library 2.Police/Customs/Metro/Court/Prison/Public Safety Pharmaceutical drugs:Heroin, Cocaine, Metamfetamine, Ketamin… Precursor:(-)-ephedrine, Chloroform, Diethyl ether… Explosives:TNT,RDX,TATP, Ammonium nitrate… Hazardous chemicals:Sulfate, Gasoline, Nitric acid, Toluene… Food Safety:Illegal food additives, residues of pesticide, veterinary drugs… 3.Pharmaceutical Factory APIs, Raw materials, Intermediate, excipients… 4,Gemstones Gemstones:Diamond, Agate, Emerald…
Export Report Export report including detect result, spectral info, evident pictures
Laser Output 350 mW
Battery 4-6 hour continuous operation
Charging Type USB Type-C
system parameter
Humidity Range 90%
Handheld Raman sets
Detector CMOS
Optical parameter
Trigger NO(Trigger on proble YES/NO)
Cooling temperature No cooling
Electrical parameter
Integration time 1ms- 30ms
Operating temperature -10 – 40 ℃


Non-destructive, Rapid ID, One-touch

Advanced algorithm, mixture detection

HD 5.5-inch capacitive touch screen, superior operation

13-Mega camera & 8-Mega Pixels

Barcode payment scan

Precision GPS positioning

GSM cloud upload

Multi-communication modes of 4G, GPS, GPRS, Bluetooth, WIFI

Export pdf report

Test results marked in tertiary colors

Battery 4-6 hrs continuous operation

Light weight(450g), easy to take;


Data Sheet:

ATR6500 System

Operative System


Excitation Wavelength

785 ± 0.5nm

Wavenumber Range

200-4000 cm-1


10 cm-1

Touch Screen

5.5", 1920×1080, Multi-point touch control






WIFI, USB Type-C, Bluetooth, GSM



Spectral Library



Self-built Spectral Library

Scientific Research


Pharmaceutical drugsHeroin, Cocaine, Metamfetamine, Ketamin…

Precursor(-)-ephedrine, Chloroform, Diethyl ether…

ExplosivesTNT,RDX,TATP, Ammonium nitrate…

Hazardous chemicalsSulfate, Gasoline, Nitric acid, Toluene…

Food SafetyIllegal food additives, residues of pesticide, veterinary drugs…

Public Safety


APIs, excipients…

Pharmaceutical Factory


GemstonesDiamond, Agate, Emerald…


Export Report

Export report including detect result, spectral info, evident pictures


4-6 hour continuous operation

Charging Type

USB Type-C

Operating Temperature

-20 – 50


Substances identification

Minerals Sorting

Experiment research

Antique identification

Gemstone identification

Drugs detection

Q - What is the ATR6500?

A-ATP6500 is an advanced handheld Raman system designed for security personnel to quickly and non-destructively identify unknown substances.
Q - What is the purpose of the ATR6500?

A-ATP6500's primary function is to provide fast, accurate first reactions or screening results for a variety of hazardous and/or illegal chemicals.
Q - Can the ATR6500 replace a laboratory-grade Raman spectrometer or a gas chromatography-mass spectrometer?

A-ATP6500 is designed to be taken directly from the lab/office/department when needed. The small size, light weight and simple interface make it the ideal equipment for first-time witnesses, customs and border patrols, security personnel and other first-class identification of substances in the field. It provides fast identification results and can be supplemented with laboratory analysis by rapid screening in the field, reducing the need to use laboratory equipment to analyze non-hazardous materials such as detergents.

Q - What can the ATP6500 identify?

A-ATP6500 can identify thousands of substances, including anesthetics, cutting agents, narcotics precursors, control substances, drugs, toxic, non-toxic chemicals, solvents, certain food materials, and so on.
Q - How many versions are there in the ATP6500 series?

A-We have ATR6500DH,ATR6500PH,ATR6500GM and ATR6500 four series.
Q - Can the ATR6500 identify those types of anesthetics?

A--The four ATR6500s recognize a wide range of illicit drugs and drugs, including but not limited to these: Heroin, fentanyl, cocaine base, cocaine hydrochloride, cocaine, amphetamine, methamphetamine, ketamine, steroids/testosterone, analgesics, methylphenidate, benzocyclidine, synthetic marijuana, ecstasy, etc.

Q - Can ATP6500 identify marijuana?

A-ATR6500's Raman technology is suitable for chemical and synthetic applications, excluding plant materials such as marijuana.
Question - Can the ATR6500 identify heroin?

A- NO. Exciting heroin with a 785 nm laser produces a strong fluorescent signal that covers the Raman signal of the substance itself, so it cannot detect the Raman signal of heroin. But ATP6600 can do it.

Question - Can the ATP6500 identify explosives?

A- Yes, ATR6500 provides a complete library of explosives for use by first responders and other users.

Q - ATR6500 allows users to add custom library items. What are its legal consequences?

A - The ATR6500's custom library feature is designed to allow global users to quickly add new, emerging or region-specific substances to their libraries if they don't already exist. This allows for the rapid identification of new threats using custom non-verified libraries. Customers are responsible for the integrity of the library content they create.

Q- Can the ATR6500D perform software and spectral library updates?

A - Optosky released a release of the software update, and the customer was informed of the availability of the library and software updates. These are provided free of charge during the warranty period.
Q - How do software and spectral library updates download and send?
A-Update notifications are sent by email. The user can then provide a secure download link from the update file installed on the computer-based TID software via a wi-fi or Ethernet connection. The user will then be guided to install updates for these tools.

Q - What is Raman spectroscopy?

A - In Raman spectroscopy, an unknown sample is illuminated by a monochromatic (single wavelength or single frequency) laser, which can be absorbed, transmitted, reflected, or scattered by the sample. The light scattered from the sample is caused by the elastic collision (Rayleigh scattering) or inelastic collision (Raman scattering) of the light with the sample molecules. Rayleigh scattered light has the same frequency (wavelength) as the incident laser light, and when Raman scattered light returns from the sample, it is affected by the vibration of molecular bonds in the sample, and the frequency of the scattered light changes compared to the incident light.

Q - How to use Raman spectrum in pharmaceutical Industry?

A - In pharmaceutical production, Raman spectrometers are suitable for the inspection of incoming raw materials, the allocation of materials during API production, and the identification of counterfeit and inferior products.

Pharmaceutical manufacturers use Raman spectrometers for raw material analysis in pharmaceutical manufacturing processes. Even non-professional operators can use hand-held Raman analyzers to quickly and accurately identify raw materials.

QA / QC applications for Raman analyzers include enhanced raw material authenticity checks for similar compounds, multi-component authenticity checks, and identification and quantification of intermediate and finished products. In PAT, specific applications include on-line end determinations for distillation, reaction monitoring, and powder mixing operations.

Counterfeit or substandard drugs are a growing problem worldwide. To protect patient and brand integrity, pharmaceutical manufacturers use portable Raman analyzers to identify counterfeit products. The portable Raman analyzer allows users without chemical training to conduct on-site screening of drug samples and quickly and accurately identify counterfeit or substandard drugs. Because the spectrum generated by TruScan RM is able to check all the ingredients in the pharmaceutical dosage form: API, excipients, fillers, dyes, coatings, etc. to produce a spectrum representing all ingredients (and their relative concentrations), any slight deviations from the original Both will cause the obtained spectrum to change. This makes ATR6500 the ideal tool to quickly detect counterfeit and inferior medicines in the field.

Q - What is the correlation of Raman spectroscopy with high-throughput screening in the pharmaceutical industry (HTS) ?

A - High-throughput screening (HTS) used in the pharmaceutical industry involves testing the collection of hundreds of samples and subsequent analysis to quickly determine the biological or biochemical activity of a large number of drug-like compounds. HTS technology is used to characterize polymers and drugs by integrating itself into the manufacturing process to provide real-time measurements. Due to the large number of samples, HTS requires a high degree of automation and a small number of sample preparation steps. Raman spectrometers meet this need and are widely used to automate HTS and analytical measurements.

Q - Can only scientists or experts use Raman technology in pharmaceutical and pharmaceutical production?

A - Some handheld Raman analyzers used in the pharmaceutical industry are specifically designed and set up for non-expert users. For example, the ATR6500 pharmaceutical handheld Raman analyzer can not only obtain the Raman spectrum of the target material, but also determine the measurement uncertainty in real time, giving relevant factors such as sample characteristics, instrument telemetry, environment, and test environment. End users of field material identification systems are usually not spectroscopic experts, so instrument data can be relied upon to convert instrument data to qualitative results.

Q - Is Raman spectrosopy suitable in USP & EP?

A - The ATR6500 Handheld Raman Spectrometer fully complies with the revised standards USP General Rules for Raman Spectroscopy <1120>. The ATR6500 enhances 21 CFR Part 11 compliance security features, such as biometric login and optional password aging and complexity, allowing users to customize the analyzer's security settings beyond regulatory requirements.

Q - Can Raman spectrometers be used to analyze tablet film coatings?

A - Pharmaceutical companies that produce tablets, capsules, and other solid dosage forms need to use film coatings on their products to differentiate the visual appearance, improve swallowing ability, and mask unpleasant tastes or odors. Film coating can also reduce cracking and chipping of tablets and provide protection from light, humidity and ambient gases. The latest handheld Raman analyzers have built-in multivariate residual analysis decision tools to identify most materials, while more complex materials analysis requires users to build custom advanced algorithms. Some handheld analyzers use built-in chemometric configurations to enable users to develop customized predictive applications, including classification, semi-quantitative, and quantitative methods, to establish pass / fail criteria to identify highly similar compounds such as tablet packs clothes).

Q - Can Raman spectroscopy be used to verify stearates and other pharmaceutical capsule lubricants?

A - Magnesium stearate is a white powder that turns into a solid at room temperature. In pharmaceutical manufacturing, magnesium stearate is the most commonly used capsule and tablet lubricant to help prevent pharmaceutical ingredients from adhering to manufacturing equipment. Calcium stearate, and to a lesser extent, zinc stearate, are also used as pharmaceutical excipients in the production process, mainly for the lubrication of tablets and capsules.

Magnesium stearate, calcium stearate, and zinc stearate have similar compound structures, so validation during the feed inspection process is more challenging. Although some pharmaceutical industry handheld Raman analyzers have built-in multivariate residual analysis decision tools to identify most materials, more complex materials analysis requires users to build custom advanced methods. Those using a built-in chemometric configuration of the Raman analyzer enable users to develop customized predictive applications, including classification, semi-quantitative, and quantitative methods, enabling users to build models that can be applied to the analyzer.

Q - Can Raman spectrometers analyze drugs through packaging?

A - Yes, the latest handheld analyzers can scan through plastic bags, glass containers, clear plastic covers, and clear plastic covers. These analyzers' point-and-measure sampling is non-contact and non-destructive, minimizing the risk of cross-contamination and operator exposure.

Q - Is Raman spectroscopy method dangerious?

 A - In Raman spectroscopy, a sample of unknown material is illuminated with a monochromatic (single wavelength or single frequency) laser. The danger of using high-power lasers must be recognized, especially when their wavelengths are in the near-infrared region of the spectrum, because they are not visible to the naked eye at this time. Fiber optic probes should be used with care and refer to relevant government regulations regarding lasers and laser classification.

The laser used in Optosky's ATR6500 is Class IIIb under the FDA CDRH classification system. Never point the instrument at yourself or others. Do not start the instrument unless a sample completely covers the laser hole. Before removing the sample from the laser hole, be sure to stop the measurement first. The manufacturer's user manual provides specific country regulations to which the analyzer laser complies.

Q - Is Raman spectroscopy destructive to pharmaceutical materials?

A - Although Raman is generally considered a non-destructive technique, conditions such as exposure time, laser power, and sample properties can also cause sample degradation. The energy transmitted by the laser depends on the exposure time and wavelength. It may change the physical state and may damage the sample.

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